Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape

Omicron SARS-CoV-2 is rapidly spreading worldwide. To delineate the impact of emerging mutations on spike’s properties, we performed systematic structural analyses on apo Omicron spike and its complexes with human ACE2 or S309 neutralizing antibody (NAb) by cryo-EM. The Omicron spike preferentially...

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Detalles Bibliográficos
Autores principales: Zhao, Zhennan, Zhou, Jingya, Tian, Mingxiong, Huang, Min, Liu, Sheng, Xie, Yufeng, Han, Pu, Bai, Chongzhi, Han, Pengcheng, Zheng, Anqi, Fu, Lutang, Gao, Yuanzhu, Peng, Qi, Li, Ying, Chai, Yan, Zhang, Zengyuan, Zhao, Xin, Song, Hao, Qi, Jianxun, Wang, Qihui, Wang, Peiyi, Gao, George F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399999/
https://www.ncbi.nlm.nih.gov/pubmed/36002453
http://dx.doi.org/10.1038/s41467-022-32665-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399999/
https://www.ncbi.nlm.nih.gov/pubmed/36002453
http://dx.doi.org/10.1038/s41467-022-32665-7

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