Directing ricin-based immunotoxins with targeting affibodies and KDEL signal peptide to cancer cells effectively induces apoptosis and tumor suppression

The plant toxin ricin, especially its cytotoxic A chain (RTA), can be genetically engineered with targeting ligands to develop specific anti-cancer recombinant immunotoxins (RITs). Here, we used affibody molecules targeting two cancer biomarkers, the receptors HER2 and EGFR, along with the KDEL sign...

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Detalles Bibliográficos
Autores principales: Park, Seong Guk, Kim, Heeyeon, Jun, Heejin, Choi, Sun Young, Kim, Eunhee, Kang, Sebyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400252/
https://www.ncbi.nlm.nih.gov/pubmed/35999603
http://dx.doi.org/10.1186/s12951-022-01601-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400252/
https://www.ncbi.nlm.nih.gov/pubmed/35999603
http://dx.doi.org/10.1186/s12951-022-01601-8

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