Synthesis and Biological Evaluation of Bicyclo[1.1.1]pentane-Containing Aromatic Lipoxin A(4) Analogues

[Image: see text] Lipoxins are important drivers of inflammation resolution, suggesting a potential therapeutic benefit. Bicyclo[1.1.1]pentanes (BCPs) are potential isosteric replacements for arenes and/or alkyl groups within drug candidates. We carried out an asymmetric synthesis of four BCP-contai...

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Detalles Bibliográficos
Autores principales: Owen, Benjamin, de Gaetano, Monica, Gaffney, Andrew, Godson, Catherine, Guiry, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400386/
https://www.ncbi.nlm.nih.gov/pubmed/35938947
http://dx.doi.org/10.1021/acs.orglett.2c02345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400386/
https://www.ncbi.nlm.nih.gov/pubmed/35938947
http://dx.doi.org/10.1021/acs.orglett.2c02345

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