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Synthesis and Biological Evaluation of Bicyclo[1.1.1]pentane-Containing Aromatic Lipoxin A(4) Analogues

[Image: see text] Lipoxins are important drivers of inflammation resolution, suggesting a potential therapeutic benefit. Bicyclo[1.1.1]pentanes (BCPs) are potential isosteric replacements for arenes and/or alkyl groups within drug candidates. We carried out an asymmetric synthesis of four BCP-contai...

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Detalles Bibliográficos
Autores principales:	Owen, Benjamin, de Gaetano, Monica, Gaffney, Andrew, Godson, Catherine, Guiry, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400386/ https://www.ncbi.nlm.nih.gov/pubmed/35938947 http://dx.doi.org/10.1021/acs.orglett.2c02345

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