Proteolytic Processing of the Coronavirus Replicase Nonstructural Protein 14 Exonuclease Is Not Required for Virus Replication but Alters RNA Synthesis and Viral Fitness

Coronaviruses (CoVs) initiate replication by translation of the positive-sense RNA genome into the replicase polyproteins connecting 16 nonstructural protein domains (nsp1-16), which are subsequently processed by viral proteases to yield mature nsp. For the betacoronavirus murine hepatitis virus (MH...

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Detalles Bibliográficos
Autores principales: Anderson-Daniels, Jordan, Gribble, Jennifer, Denison, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400476/
https://www.ncbi.nlm.nih.gov/pubmed/35924922
http://dx.doi.org/10.1128/jvi.00841-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400476/
https://www.ncbi.nlm.nih.gov/pubmed/35924922
http://dx.doi.org/10.1128/jvi.00841-22

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