Cargando…

Proteolytic Processing of the Coronavirus Replicase Nonstructural Protein 14 Exonuclease Is Not Required for Virus Replication but Alters RNA Synthesis and Viral Fitness

Coronaviruses (CoVs) initiate replication by translation of the positive-sense RNA genome into the replicase polyproteins connecting 16 nonstructural protein domains (nsp1-16), which are subsequently processed by viral proteases to yield mature nsp. For the betacoronavirus murine hepatitis virus (MH...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anderson-Daniels, Jordan, Gribble, Jennifer, Denison, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400476/ https://www.ncbi.nlm.nih.gov/pubmed/35924922 http://dx.doi.org/10.1128/jvi.00841-22

Ejemplares similares

nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity
por: Lello, Laura Sandra, et al.
Publicado: (2021)

Activity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus
por: Lello, Laura Sandra, et al.
Publicado: (2022)

Identification of a Proline-Kinked Amphipathic α-Helix Downstream from the Methyltransferase Domain of a Potexvirus Replicase and Its Role in Virus Replication and Perinuclear Complex Formation
por: Komatsu, Ken, et al.
Publicado: (2021)

Identification and Characterization of a Human Coronavirus 229E Nonstructural Protein 8-Associated RNA 3′-Terminal Adenylyltransferase Activity
por: Tvarogová, Jana, et al.
Publicado: (2019)

DNAJC14-Independent Replication of the Atypical Porcine Pestivirus
por: Reuscher, Carina M., et al.
Publicado: (2022)

A Nonstructural Protein Responsible for Viral Spread of a Novel Insect Reovirus Provides a Safe Channel for Biparental Virus Transmission to Progeny
por: Chen, Qian, et al.
Publicado: (2019)

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2
por: Ogando, Natacha S., et al.
Publicado: (2020)

Analysis of Coronavirus Temperature-Sensitive Mutants Reveals an Interplay between the Macrodomain and Papain-Like Protease Impacting Replication and Pathogenesis
por: Deng, Xufang, et al.
Publicado: (2019)

An A14U Substitution in the 3′ Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs
por: Zheng, Min, et al.
Publicado: (2015)

Human Choline Kinase-α Promotes Hepatitis C Virus RNA Replication through Modulation of Membranous Viral Replication Complex Formation
por: Wong, Mun-Teng, et al.
Publicado: (2016)

Analysis of Paramyxovirus Transcription and Replication by High-Throughput Sequencing
por: Wignall-Fleming, Elizabeth B., et al.
Publicado: (2019)

A Mechanism for Priming and Realignment during Influenza A Virus Replication
por: Oymans, Judith, et al.
Publicado: (2018)

In Vivo Labelling of Adenovirus DNA Identifies Chromatin Anchoring and Biphasic Genome Replication
por: Komatsu, Tetsuro, et al.
Publicado: (2018)

Viral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide Depletion
por: Stapleford, Kenneth A., et al.
Publicado: (2015)

Modulation of Stop Codon Read-Through Efficiency and Its Effect on the Replication of Murine Leukemia Virus
por: Csibra, Eszter, et al.
Publicado: (2014)

Oligomerization of the Vesicular Stomatitis Virus Phosphoprotein Is Dispensable for mRNA Synthesis but Facilitates RNA Replication
por: Bloyet, Louis-Marie, et al.
Publicado: (2020)

The SARS-CoV nsp12 Polymerase Active Site Is Tuned for Large-Genome Replication
por: Campagnola, Grace, et al.
Publicado: (2022)

Insights into Polyprotein Processing and RNA-Protein Interactions in Foot-and-Mouth Disease Virus Genome Replication
por: Pierce, Danielle M., et al.
Publicado: (2023)

Uncoupling of Influenza A Virus Transcription and Replication through Mutation of the Unpaired Adenosine in the Viral RNA Promoter
por: te Velthuis, Aartjan J. W., et al.
Publicado: (2013)

Polyprotein-Driven Formation of Two Interdependent Sets of Complexes Supporting Hepatitis C Virus Genome Replication
por: Gomes, Rafael G. B., et al.
Publicado: (2016)

Nucleocapsid Protein Recruitment to Replication-Transcription Complexes Plays a Crucial Role in Coronaviral Life Cycle
por: Cong, Yingying, et al.
Publicado: (2020)

The Surface-Exposed PA(51-72)-Loop of the Influenza A Virus Polymerase Is Required for Viral Genome Replication
por: Nilsson-Payant, Benjamin E., et al.
Publicado: (2018)

Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication
por: Herod, Morgan R., et al.
Publicado: (2016)

Kaposi’s Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis
por: Pringle, Eric S., et al.
Publicado: (2019)

Experimental Evolution Generates Novel Oncolytic Vesicular Stomatitis Viruses with Improved Replication in Virus-Resistant Pancreatic Cancer Cells
por: Seegers, Sara L., et al.
Publicado: (2020)

Mutational Disruption of cis-Acting Replication Element 2C in Coxsackievirus B3 Leads to 5′-Terminal Genomic Deletions
por: Smithee, S., et al.
Publicado: (2015)

Differentiation-Coupled Induction of Human Cytomegalovirus Replication by Union of the Major Enhancer Retinoic Acid, Cyclic AMP, and NF-κB Response Elements
por: Yuan, Jinxiang, et al.
Publicado: (2015)

Stimulation of the Replication of ICP0-Null Mutant Herpes Simplex Virus 1 and pp71-Deficient Human Cytomegalovirus by Epstein-Barr Virus Tegument Protein BNRF1
por: Lu, Yongxu, et al.
Publicado: (2016)

Lost Small Envelope Protein Expression from Naturally Occurring PreS1 Deletion Mutants of Hepatitis B Virus Is Often Accompanied by Increased HBx and Core Protein Expression as Well as Genome Replication
por: Fu, Shuwen, et al.
Publicado: (2021)

The Human Adenovirus 5 L4 Promoter Is Activated by Cellular Stress Response Protein p53
por: Wright, Jordan, et al.
Publicado: (2013)

Hepatitis C Virus Subverts Human Choline Kinase-α To Bridge Phosphatidylinositol-4-Kinase IIIα (PI4KIIIα) and NS5A and Upregulates PI4KIIIα Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication
por: Wong, Mun-Teng, et al.
Publicado: (2017)

The Human Adenovirus Type 5 L4 Promoter Is Negatively Regulated by TFII-I and L4-33K
por: Wright, Jordan, et al.
Publicado: (2015)

Establishment of a Virulent Full-Length cDNA Clone for Type I Feline Coronavirus Strain C3663
por: Terada, Yutaka, et al.
Publicado: (2019)

Deletion of the s2m RNA Structure in the Avian Coronavirus Infectious Bronchitis Virus and Human Astrovirus Results in Sequence Insertions
por: Keep, Sarah, et al.
Publicado: (2023)

Insights into the Complexity and Functionality of Hepatitis C Virus NS5A Phosphorylation
por: Ross-Thriepland, Douglas, et al.
Publicado: (2014)

An Avian Retrovirus Uses Canonical Expression and Processing Mechanisms To Generate Viral MicroRNA
por: Yao, Yongxiu, et al.
Publicado: (2014)

CCCTC-Binding Factor Recruitment to the Early Region of the Human Papillomavirus 18 Genome Regulates Viral Oncogene Expression
por: Paris, Christian, et al.
Publicado: (2015)

Characterization of Ribosomal Frameshifting in Theiler's Murine Encephalomyelitis Virus
por: Finch, Leanne K., et al.
Publicado: (2015)

MicroRNA-Detargeted Mengovirus for Oncolytic Virotherapy
por: Ruiz, Autumn J., et al.
Publicado: (2016)

A Subset of CD4/CD8 Double-Negative T Cells Expresses HIV Proteins in Patients on Antiretroviral Therapy
por: DeMaster, Laura K., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_i1g8i53kul7sjddsdvr4iuu9bn