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Non-ergodicity of a globular protein extending beyond its functional timescale

Internal motions of folded proteins have been assumed to be ergodic, i.e., that the dynamics of a single protein molecule averaged over a very long time resembles that of an ensemble. Here, by performing single-molecule fluorescence resonance energy transfer (smFRET) experiments and molecular dynami...

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Detalles Bibliográficos
Autores principales: Li, Jun, Xie, JingFei, Godec, Aljaž, Weninger, Keith R., Liu, Cong, Smith, Jeremy C., Hong, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400594/
https://www.ncbi.nlm.nih.gov/pubmed/36091909
http://dx.doi.org/10.1039/d2sc03069a