Hexafluoroisobutylation of enolates through a tandem elimination/allylic shift/hydrofluorination reaction

The isobutyl side chain is a highly prevalent hydrophobic group in drugs, and it notably constitutes the side chain of leucine. Its replacement by a hexafluorinated version containing two CF(3) groups may endow the target compound with new and advantageous properties, yet this modification remains o...

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Detalles Bibliográficos
Autores principales: Delamare, Aline, Naulet, Guillaume, Kauffmann, Brice, Guichard, Gilles, Compain, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400614/
https://www.ncbi.nlm.nih.gov/pubmed/36091907
http://dx.doi.org/10.1039/d2sc02871a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400614/
https://www.ncbi.nlm.nih.gov/pubmed/36091907
http://dx.doi.org/10.1039/d2sc02871a

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