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Hexafluoroisobutylation of enolates through a tandem elimination/allylic shift/hydrofluorination reaction
The isobutyl side chain is a highly prevalent hydrophobic group in drugs, and it notably constitutes the side chain of leucine. Its replacement by a hexafluorinated version containing two CF(3) groups may endow the target compound with new and advantageous properties, yet this modification remains o...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400614/ https://www.ncbi.nlm.nih.gov/pubmed/36091907 http://dx.doi.org/10.1039/d2sc02871a |