One-pot two-step catalytic synthesis of 6-amino-2-pyridone-3,5-dicarbonitriles enabling anti-cancer bioactivity

We report a one-pot two-step synthesis of a bioactive 6-amino-2-pyridone-3,5-dicarbonitrile derivative using natural product catalysts betaine and guanidine carbonate. Anti-cancer bioactivity was observed in specific molecules within the library of 16 derivatives. Out of the compounds, 5o had the mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Nicely, Lynden G., Vala, Ruturajsinh M., Upadhyay, Dipti B., Nogales, Joaquina, Chi, Celestine, Banerjee, Sourav, Patel, Hitendra M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400646/
https://www.ncbi.nlm.nih.gov/pubmed/36093229
http://dx.doi.org/10.1039/d2ra03579k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400646/
https://www.ncbi.nlm.nih.gov/pubmed/36093229
http://dx.doi.org/10.1039/d2ra03579k

Ejemplares similares