Novel approaches for the rational design of PROTAC linkers

Proteolysis targeting chimeras (PROTACs) represent a promising class of hetero-bivalent molecules that facilitate ubiquitination of a target protein by simultaneously binding and bringing together both the E3 enzyme and the target. These compounds consist of three structural components: two ligands...

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Detalles Bibliográficos
Autores principales: Zagidullin, Almaz, Milyukov, Vasili, Rizvanov, Albert, Bulatov, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400696/
https://www.ncbi.nlm.nih.gov/pubmed/36046487
http://dx.doi.org/10.37349/etat.2020.00023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400696/
https://www.ncbi.nlm.nih.gov/pubmed/36046487
http://dx.doi.org/10.37349/etat.2020.00023

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