Allosteric cross-talk between the hydrophobic cleft and the BH4 domain of Bcl-2 in control of inositol 1,4,5-trisphosphate receptor activity

AIM: Inositol 1,4,5-trisphosphate receptor (IP(3)R) is a ubiquitous calcium (Ca(2+)) channel involved in the regulation of cellular fate and motility. Its modulation by anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) plays an important role in cancer progression. Disrupting this interaction could o...

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Detalles Bibliográficos
Autores principales: Shapovalov, George, Ritaine, Abigaël, Essonghe, Nadege Charlene, de Ridder, Ian, Ivanova, Hristina, Karamanou, Spyridoula, Economou, Anastassios, Bultynck, Geert, Skryma, Roman, Prevarskaya, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400710/
https://www.ncbi.nlm.nih.gov/pubmed/36045908
http://dx.doi.org/10.37349/etat.2022.00088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400710/
https://www.ncbi.nlm.nih.gov/pubmed/36045908
http://dx.doi.org/10.37349/etat.2022.00088

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