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Physical characteristics comparison between maytansinoid-based and auristatin-based antibody-drug conjugates
AIM: Direct analytical comparison of two major drug-linkers in the antibody-drug conjugate (ADC) field was conducted. METHODS: Four different analytical methods [AlogP calculation, reverse phase (RP) high-performance liquid chromatography (HPLC; RP-HPLC), size exclusion chromatography HPLC (SEC-HPLC...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Open Exploration
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400747/ https://www.ncbi.nlm.nih.gov/pubmed/36046112 http://dx.doi.org/10.37349/etat.2021.00064 |