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Continuous Flow Preparation of Benzylic Sodium Organometallics
We report a lateral sodiation of alkyl(hetero)arenes using on‐demand generated hexane‐soluble (2‐ethylhexyl)sodium (1) in the presence of TMEDA. (2‐Ethylhexyl)sodium (1) is prepared via a sodium packed‐bed reactor and used for metalations at ambient temperature in batch as well as in continuous flow...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400861/ https://www.ncbi.nlm.nih.gov/pubmed/35416397 http://dx.doi.org/10.1002/anie.202203807 |