Broad‐Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve‐Agent‐Inhibited Acetylcholinesterase

Reactivators are vital for the treatment of organophosphorus nerve agent (OPNA) intoxication but new alternatives are needed due to their limited clinical applicability. The toxicity of OPNAs stems from covalent inhibition of the essential enzyme acetylcholinesterase (AChE), which reactivators relie...

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Detalles Bibliográficos
Autores principales: Lindgren, Cecilia, Forsgren, Nina, Hoster, Norman, Akfur, Christine, Artursson, Elisabet, Edvinsson, Lotta, Svensson, Richard, Worek, Franz, Ekström, Fredrik, Linusson, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400889/
https://www.ncbi.nlm.nih.gov/pubmed/35420233
http://dx.doi.org/10.1002/chem.202200678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400889/
https://www.ncbi.nlm.nih.gov/pubmed/35420233
http://dx.doi.org/10.1002/chem.202200678

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