Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties

Poly(A)‐binding protein (PABP) is an essential element of cellular translational machinery. Recent studies have revealed that poly(A) tail modifications can modulate mRNA stability and translational potential, and that oligoadenylate‐derived PABP ligands can act as effective translational inhibitors...

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Detalles Bibliográficos
Autores principales: Perzanowska, Olga, Smietanski, Miroslaw, Jemielity, Jacek, Kowalska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400960/
https://www.ncbi.nlm.nih.gov/pubmed/35575378
http://dx.doi.org/10.1002/chem.202201115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400960/
https://www.ncbi.nlm.nih.gov/pubmed/35575378
http://dx.doi.org/10.1002/chem.202201115

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