Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization

A Ru(bpy)(3)Cl(2) photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene‐containing pharmacological agents, including combretastatin A‐4 (CA‐4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to pot...

Descripción completa

Detalles Bibliográficos
Autores principales: Watson, Emma E., Russo, Francesco, Moreau, Dimitri, Winssinger, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400970/
https://www.ncbi.nlm.nih.gov/pubmed/35510306
http://dx.doi.org/10.1002/anie.202203390
Descripción
Sumario:A Ru(bpy)(3)Cl(2) photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene‐containing pharmacological agents, including combretastatin A‐4 (CA‐4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA‐4 analog Res‐3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics.

Ejemplares similares