Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization

A Ru(bpy)(3)Cl(2) photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene‐containing pharmacological agents, including combretastatin A‐4 (CA‐4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to pot...

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Autores principales: Watson, Emma E., Russo, Francesco, Moreau, Dimitri, Winssinger, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400970/
https://www.ncbi.nlm.nih.gov/pubmed/35510306
http://dx.doi.org/10.1002/anie.202203390
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author Watson, Emma E.
Russo, Francesco
Moreau, Dimitri
Winssinger, Nicolas
author_facet Watson, Emma E.
Russo, Francesco
Moreau, Dimitri
Winssinger, Nicolas
author_sort Watson, Emma E.
collection PubMed
description A Ru(bpy)(3)Cl(2) photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene‐containing pharmacological agents, including combretastatin A‐4 (CA‐4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA‐4 analog Res‐3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics.
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spelling pubmed-94009702022-08-26 Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization Watson, Emma E. Russo, Francesco Moreau, Dimitri Winssinger, Nicolas Angew Chem Int Ed Engl Research Articles A Ru(bpy)(3)Cl(2) photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene‐containing pharmacological agents, including combretastatin A‐4 (CA‐4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA‐4 analog Res‐3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics. John Wiley and Sons Inc. 2022-05-20 2022-07-11 /pmc/articles/PMC9400970/ /pubmed/35510306 http://dx.doi.org/10.1002/anie.202203390 Text en © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Watson, Emma E.
Russo, Francesco
Moreau, Dimitri
Winssinger, Nicolas
Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization
title Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization
title_full Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization
title_fullStr Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization
title_full_unstemmed Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization
title_short Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization
title_sort optochemical control of therapeutic agents through photocatalyzed isomerization
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400970/
https://www.ncbi.nlm.nih.gov/pubmed/35510306
http://dx.doi.org/10.1002/anie.202203390
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AT winssingernicolas optochemicalcontroloftherapeuticagentsthroughphotocatalyzedisomerization

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