Total Synthesis of Mutanobactins A, B from the Human Microbiome: Macrocyclization and Thiazepanone Assembly in a Single Step

We report the first total syntheses of tricyclic mutanobactins A and B, lipopeptides incorporating a thiazepanone, isolated from Streptococcus mutans, a member of the human oral microbiome. A rapid, solid‐phase peptide synthesis (SPPS) based route delivers these natural products from a cascade of cy...

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Detalles Bibliográficos
Autores principales: Hansen, Moritz E., Yasmin, Samuel O., Wolfrum, Susanne, Carreira, Erick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400992/
https://www.ncbi.nlm.nih.gov/pubmed/35593892
http://dx.doi.org/10.1002/anie.202203051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400992/
https://www.ncbi.nlm.nih.gov/pubmed/35593892
http://dx.doi.org/10.1002/anie.202203051

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