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Total Synthesis of Mutanobactins A, B from the Human Microbiome: Macrocyclization and Thiazepanone Assembly in a Single Step
We report the first total syntheses of tricyclic mutanobactins A and B, lipopeptides incorporating a thiazepanone, isolated from Streptococcus mutans, a member of the human oral microbiome. A rapid, solid‐phase peptide synthesis (SPPS) based route delivers these natural products from a cascade of cy...
Autores principales: | Hansen, Moritz E., Yasmin, Samuel O., Wolfrum, Susanne, Carreira, Erick M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400992/ https://www.ncbi.nlm.nih.gov/pubmed/35593892 http://dx.doi.org/10.1002/anie.202203051 |
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