Cargando…

Advances towards Cell‐Specific Gene Transfection: A Small‐Molecule Approach Allows Order‐of‐Magnitude Selectivity

A transfection vector that can home in on tumors is reported. Whereas previous vectors that allow moderately cell selective gene transfection used larger systems, this small‐molecule approach paved the way for precise structure‐activity relationship optimization. For this, biotin, which mediates cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dirksmeyer, Thies, Stahl, Paul, Vallet, Cecilia, Knauer, Shirley, Giese, Michael, Schmuck, Carsten, Hirschhäuser, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401007/ https://www.ncbi.nlm.nih.gov/pubmed/35604769 http://dx.doi.org/10.1002/chem.202104618

Ejemplares similares

Cancer‐Cell‐Specific Drug Delivery by a Tumor‐Homing CPP‐Gossypol Conjugate Employing a Tracelessly Cleavable Linker
por: Maity, Suman Kumar, et al.
Publicado: (2020)

Functional Disruption of the Cancer‐Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole Ligand
por: Vallet, Cecilia, et al.
Publicado: (2020)

Selective Disruption of Survivin's Protein‐Protein Interactions: A Supramolecular Approach Based on Guanidiniocarbonylpyrrole
por: Aschmann, Dennis, et al.
Publicado: (2022)

Luminescent Amphiphilic Aminoglycoside Probes to Study Transfection
por: Zimmermann, Alexander, et al.
Publicado: (2021)

A Metallosupramolecular Coordination Polymer for the ‘Turn‐on’ Fluorescence Detection of Hydrogen Sulfide
por: Hatai, Joydev, et al.
Publicado: (2020)

Computational model predicts protein binding sites of a luminescent ligand equipped with guanidiniocarbonyl-pyrrole groups
por: Rafieiolhosseini, Neda, et al.
Publicado: (2022)

Supramolecular polymers with reversed viscosity/temperature profile for application in motor oils
por: Ostwaldt, Jan-Erik, et al.
Publicado: (2021)

A Selective Cucurbit[8]uril‐Peptide Beacon Ensemble for the Ratiometric Fluorescence Detection of Peptides
por: Maity, Debabrata, et al.
Publicado: (2019)

Spatial and Temporal Control of Cavitation Allows High In Vitro Transfection Efficiency in the Absence of Transfection Reagents or Contrast Agents
por: Chettab, Kamel, et al.
Publicado: (2015)

Is Order the Defining Feature of Magnitude Representation? An ERP Study on Learning Numerical Magnitude and Spatial Order of Artificial Symbols
por: Zhao, Hui, et al.
Publicado: (2012)

Effect of small molecule signaling in PepFect14 transfection
por: Gestin, Maxime, et al.
Publicado: (2020)

Impact of Peptide Sequences on Their Structure and Function: Mimicking of Virus‐Like Nanoparticles for Nucleic Acid Delivery
por: Jana, Poulami, et al.
Publicado: (2022)

Lipofection with estrone-based luminophores featuring aggregation-induced emission properties
por: Riebe, Steffen, et al.
Publicado: (2020)

GPI-anchored glutathione S-transferase as marker allows affinity sorting of transfection-positive cells
por: Ma, Shumin, et al.
Publicado: (2022)

On the order of magnitude of 8th order corrections to the anomalous magnetic moment of the muon
por: Lautrup, B
Publicado: (1972)

Orders of Magnitude Change in Phenotype Rate Caused by Mutation
por: Ao, Ping
Publicado: (2007)

Orders of Magnitude Change in Phenotype Rate Caused by Mutation
por: Duesberg, Peter, et al.
Publicado: (2007)

Toward Contactless Biology: Acoustophoretic DNA Transfection
por: Vasileiou, Thomas, et al.
Publicado: (2016)

A Supramolecular Stabilizer of the 14‐3‐3ζ/ERα Protein‐Protein Interaction with a Synergistic Mode of Action
por: Gigante, Alba, et al.
Publicado: (2020)

Systematic Screening of Commonly Used Commercial Transfection Reagents towards Efficient Transfection of Single-Stranded Oligonucleotides
por: Wang, Tao, et al.
Publicado: (2018)

The role of numerical magnitude and order in the illusory perception of size and brightness
por: Viarouge, Arnaud, et al.
Publicado: (2013)

In situ Stiffness Adjustment of AFM Probes by Two Orders of Magnitude
por: de Laat, Marcel Lambertus Cornelis, et al.
Publicado: (2016)

Boosting nanotoxicity to combat multidrug-resistant bacteria in pathophysiological environments
por: Westmeier, Dana, et al.
Publicado: (2020)

Monitoring the photochemistry of a formazan over 15 orders of magnitude in time
por: Wortmann, Svenja, et al.
Publicado: (2022)

Rational Mutagenesis in the Lid Domain of Ribokinase from E. coli Results in an Order of Magnitude Increase in Activity towards D-arabinose
por: Zayats, Evgeniy A., et al.
Publicado: (2022)

Poly(ethylene glycol)-Based Peptidomimetic “PEGtide” of Oligo-Arginine Allows for Efficient siRNA Transfection and Gene Inhibition
por: Hibbitts, Alan, et al.
Publicado: (2019)

Suppression of mRNA Nanoparticle Transfection in Human Fibroblasts by Selected Interferon Inhibiting Small Molecule Compounds
por: Liu, Yang, et al.
Publicado: (2017)

Bioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of MET
por: Kim, Eunha, et al.
Publicado: (2013)

The astronomers' magic envelope: an introduction to astrophysics emphasizing general principles and orders of magnitude
por: Saha, Prasenjit, et al.
Publicado: (2018)

10 Orders of Magnitude Current Measurement Digitisers for the CERN Beam Loss Systems
por: Vigano, W, et al.
Publicado: (2013)

Tachyon search speeds up retrieval of similar sequences by several orders of magnitude
por: Tan, Joshua, et al.
Publicado: (2012)

Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics
por: Lu, Guihong, et al.
Publicado: (2019)

Diffraction response of photorefractive polymers over nine orders of magnitude of pulse duration
por: Blanche, Pierre-Alexandre, et al.
Publicado: (2016)

Reducing medical device alarms by an order of magnitude: A human factors approach
por: Koomen, Erik, et al.
Publicado: (2021)

Modulating Hyperpolarization-Activated Cation Currents through Small Molecule Perturbations: Magnitude and Gating Control
por: Chen, Cheng-Shih, et al.
Publicado: (2023)

The challenging nature of primary T lymphocytes for transfection: Effect of protamine sulfate on the transfection efficiency of chemical transfection reagents
por: Rahimmanesh, Ilnaz, et al.
Publicado: (2020)

Transfection of Platyhelminthes
por: Moguel, Bárbara, et al.
Publicado: (2015)

Reverse Expression of Aging-Associated Molecules through Transfection of miRNAs to Aged Mice
por: Kim, Jung-Hee, et al.
Publicado: (2017)

Effect of the array of amines on the transfection efficiency of cationic peptidomimetic lipid molecules into neural cells
por: Yu, Xiang, et al.
Publicado: (2022)

Preparing for HL-LHC: Increasing the LHCb software publication rate to CVMFS by an order of magnitude
por: Bocchi, Enrico
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hsjo3bm0rr76g3502hqrbdanpd