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Spectroscopic and in vitro Investigations of Fe(2+)/α‐Ketoglutarate‐Dependent Enzymes Involved in Nucleic Acid Repair and Modification

The activation of molecular oxygen for the highly selective functionalization and repair of DNA and RNA nucleobases is achieved by α‐ketoglutarate (α‐KG)/iron‐dependent dioxygenases. Of special interest are the human homologues AlkBH of Escherichia coli EcAlkB and ten‐eleven translocation (TET) enzy...

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Detalles Bibliográficos
Autores principales: Schmidl, David, Lindlar né Jonasson, Niko S. W., Menke, Annika, Schneider, Sabine, Daumann, Lena J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401043/
https://www.ncbi.nlm.nih.gov/pubmed/35040547
http://dx.doi.org/10.1002/cbic.202100605