Widely Distributed Bifunctional Bacterial Cytochrome P450 Enzymes Catalyze both Intramolecular C−C Bond Formation in cyclo‐l‐Tyr‐l‐Tyr and Its Coupling with Nucleobases

Tailoring enzymes are important modification biocatalysts in natural product biosynthesis. We report herein six orthologous two‐gene clusters for mycocyclosin and guatyromycine biosynthesis. Expression of the cyclodipeptide synthase genes gymA(1) –gymA(6) in Escherichia coli resulted in the formatio...

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Detalles Bibliográficos
Autores principales: Liu, Jing, Harken, Lauritz, Yang, Yiling, Xie, Xiulan, Li, Shu‐Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401060/
https://www.ncbi.nlm.nih.gov/pubmed/35201649
http://dx.doi.org/10.1002/anie.202200377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401060/
https://www.ncbi.nlm.nih.gov/pubmed/35201649
http://dx.doi.org/10.1002/anie.202200377

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