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Widely Distributed Bifunctional Bacterial Cytochrome P450 Enzymes Catalyze both Intramolecular C−C Bond Formation in cyclo‐l‐Tyr‐l‐Tyr and Its Coupling with Nucleobases
Tailoring enzymes are important modification biocatalysts in natural product biosynthesis. We report herein six orthologous two‐gene clusters for mycocyclosin and guatyromycine biosynthesis. Expression of the cyclodipeptide synthase genes gymA(1) –gymA(6) in Escherichia coli resulted in the formatio...
Autores principales: | Liu, Jing, Harken, Lauritz, Yang, Yiling, Xie, Xiulan, Li, Shu‐Ming |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401060/ https://www.ncbi.nlm.nih.gov/pubmed/35201649 http://dx.doi.org/10.1002/anie.202200377 |
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