A Practical and Scalable Approach to Fluoro‐Substituted Bicyclo[1.1.1]pentanes

After more than 20 years of trials, a practical scalable approach to fluoro‐substituted bicyclo[1.1.1]pentanes (F‐BCPs) has been developed. The physicochemical properties of the F‐BCPs have been studied, and the core was incorporated into the structure of the anti‐inflammatory drug Flurbiprofen in p...

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Detalles Bibliográficos
Autores principales: Bychek, Roman, Mykhailiuk, Pavel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401599/
https://www.ncbi.nlm.nih.gov/pubmed/35638404
http://dx.doi.org/10.1002/anie.202205103
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author Bychek, Roman
Mykhailiuk, Pavel K.
author_facet Bychek, Roman
Mykhailiuk, Pavel K.
author_sort Bychek, Roman
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description After more than 20 years of trials, a practical scalable approach to fluoro‐substituted bicyclo[1.1.1]pentanes (F‐BCPs) has been developed. The physicochemical properties of the F‐BCPs have been studied, and the core was incorporated into the structure of the anti‐inflammatory drug Flurbiprofen in place of the fluorophenyl ring.
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spelling pubmed-94015992022-08-26 A Practical and Scalable Approach to Fluoro‐Substituted Bicyclo[1.1.1]pentanes Bychek, Roman Mykhailiuk, Pavel K. Angew Chem Int Ed Engl Communications After more than 20 years of trials, a practical scalable approach to fluoro‐substituted bicyclo[1.1.1]pentanes (F‐BCPs) has been developed. The physicochemical properties of the F‐BCPs have been studied, and the core was incorporated into the structure of the anti‐inflammatory drug Flurbiprofen in place of the fluorophenyl ring. John Wiley and Sons Inc. 2022-06-14 2022-07-18 /pmc/articles/PMC9401599/ /pubmed/35638404 http://dx.doi.org/10.1002/anie.202205103 Text en © 2022 The Authors. Published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Bychek, Roman
Mykhailiuk, Pavel K.
A Practical and Scalable Approach to Fluoro‐Substituted Bicyclo[1.1.1]pentanes
title A Practical and Scalable Approach to Fluoro‐Substituted Bicyclo[1.1.1]pentanes
title_full A Practical and Scalable Approach to Fluoro‐Substituted Bicyclo[1.1.1]pentanes
title_fullStr A Practical and Scalable Approach to Fluoro‐Substituted Bicyclo[1.1.1]pentanes
title_full_unstemmed A Practical and Scalable Approach to Fluoro‐Substituted Bicyclo[1.1.1]pentanes
title_short A Practical and Scalable Approach to Fluoro‐Substituted Bicyclo[1.1.1]pentanes
title_sort practical and scalable approach to fluoro‐substituted bicyclo[1.1.1]pentanes
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401599/
https://www.ncbi.nlm.nih.gov/pubmed/35638404
http://dx.doi.org/10.1002/anie.202205103
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