Molecular basis of hUHRF1 allosteric activation for synergistic histone modification binding by PI5P

Chromatin marks are recognized by distinct binding modules, many of which are embedded in multidomain proteins. How the different functionalities of such complex chromatin modulators are regulated is often unclear. Here, we delineated the interplay of the H3 amino terminus– and K9me-binding activiti...

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Detalles Bibliográficos
Autores principales: Mandal, Papita, Eswara, Karthik, Yerkesh, Zhadyra, Kharchenko, Vladlena, Zandarashvili, Levani, Szczepski, Kacper, Bensaddek, Dalila, Jaremko, Łukasz, Black, Ben E., Fischle, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401617/
https://www.ncbi.nlm.nih.gov/pubmed/36001657
http://dx.doi.org/10.1126/sciadv.abl9461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401617/
https://www.ncbi.nlm.nih.gov/pubmed/36001657
http://dx.doi.org/10.1126/sciadv.abl9461

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