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Molecular basis of hUHRF1 allosteric activation for synergistic histone modification binding by PI5P
Chromatin marks are recognized by distinct binding modules, many of which are embedded in multidomain proteins. How the different functionalities of such complex chromatin modulators are regulated is often unclear. Here, we delineated the interplay of the H3 amino terminus– and K9me-binding activiti...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401617/ https://www.ncbi.nlm.nih.gov/pubmed/36001657 http://dx.doi.org/10.1126/sciadv.abl9461 |