Transcription factor–nucleosome dynamics from plasma cfDNA identifies ER-driven states in breast cancer

Genome-wide binding profiles of estrogen receptor (ER) and FOXA1 reflect cancer state in ER(+) breast cancer. However, routine profiling of tumor transcription factor (TF) binding is impractical in the clinic. Here, we show that plasma cell-free DNA (cfDNA) contains high-resolution ER and FOXA1 tumo...

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Detalles Bibliográficos
Autores principales: Rao, Satyanarayan, Han, Amy L., Zukowski, Alexis, Kopin, Etana, Sartorius, Carol A., Kabos, Peter, Ramachandran, Srinivas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401618/
https://www.ncbi.nlm.nih.gov/pubmed/36001652
http://dx.doi.org/10.1126/sciadv.abm4358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401618/
https://www.ncbi.nlm.nih.gov/pubmed/36001652
http://dx.doi.org/10.1126/sciadv.abm4358

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