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Transcription factor–nucleosome dynamics from plasma cfDNA identifies ER-driven states in breast cancer

Genome-wide binding profiles of estrogen receptor (ER) and FOXA1 reflect cancer state in ER(+) breast cancer. However, routine profiling of tumor transcription factor (TF) binding is impractical in the clinic. Here, we show that plasma cell-free DNA (cfDNA) contains high-resolution ER and FOXA1 tumo...

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Detalles Bibliográficos
Autores principales:	Rao, Satyanarayan, Han, Amy L., Zukowski, Alexis, Kopin, Etana, Sartorius, Carol A., Kabos, Peter, Ramachandran, Srinivas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401618/ https://www.ncbi.nlm.nih.gov/pubmed/36001652 http://dx.doi.org/10.1126/sciadv.abm4358

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