AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination

Immunoglobulin class switch recombination (CSR) plays critical roles in controlling infections and inflammatory tissue injuries. Here, we show that AFF3, a candidate gene for both rheumatoid arthritis and type 1 diabetes, is a molecular facilitator of CSR with an isotype preference. Aff3-deficient m...

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Detalles Bibliográficos
Autores principales: Tsukumo, Shin-ichi, Subramani, Poorani Ganesh, Seija, Noé, Tabata, Mizuho, Maekawa, Yoichi, Mori, Yuya, Ishifune, Chieko, Itoh, Yasushi, Ota, Mineto, Fujio, Keishi, Di Noia, Javier M., Yasutomo, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401627/
https://www.ncbi.nlm.nih.gov/pubmed/36001653
http://dx.doi.org/10.1126/sciadv.abq0008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401627/
https://www.ncbi.nlm.nih.gov/pubmed/36001653
http://dx.doi.org/10.1126/sciadv.abq0008

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