Total Synthesis of (+)‐Cochlearol B by an Approach Based on a Catellani Reaction and Visible‐Light‐Enabled [2+2] Cycloaddition

A 14‐step synthesis of (+)‐cochlearol B is reported. This renoprotective meroterpenoid features a unique core structure containing a densely substituted cyclobutane ring with three stereocenters. Our strategy employed an organocatalytic Kabbe condensation in route to the key chromenyl triflate. A su...

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Detalles Bibliográficos
Autores principales: Richardson, Alistair D., Vogel, Trenton R., Traficante, Emily F., Glover, Kason J., Schindler, Corinna S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401860/
https://www.ncbi.nlm.nih.gov/pubmed/35417620
http://dx.doi.org/10.1002/anie.202201213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401860/
https://www.ncbi.nlm.nih.gov/pubmed/35417620
http://dx.doi.org/10.1002/anie.202201213

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