Liquid Phase Separation of NEMO Induced by Polyubiquitin Chains Activates NF-κB

The NF-κB essential modulator (NEMO) is a regulatory subunit of the IκB kinase (IKK) complex that phosphorylates the NF-κB inhibitors IκBs. NEMO mediates IKK activation by binding to polyubiquitin chains (polyUb). Here we show that Lys63(K63)-linked or linear polyUb binding to NEMO robustly induced...

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Detalles Bibliográficos
Autores principales: Du, Mingjian, Ea, Chee-Kwee, Fang, Yan, Chen, Zhijian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402427/
https://www.ncbi.nlm.nih.gov/pubmed/35477005
http://dx.doi.org/10.1016/j.molcel.2022.03.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402427/
https://www.ncbi.nlm.nih.gov/pubmed/35477005
http://dx.doi.org/10.1016/j.molcel.2022.03.037

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