Diverse mutational landscapes in human lymphocytes

The lymphocyte genome is prone to many threats, including programmed mutation during differentiation(1), antigen-driven proliferation and residency in diverse microenvironments. Here, after developing protocols for expansion of single-cell lymphocyte cultures, we sequenced whole genomes from 717 nor...

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Detalles Bibliográficos
Autores principales: Machado, Heather E., Mitchell, Emily, Øbro, Nina F., Kübler, Kirsten, Davies, Megan, Leongamornlert, Daniel, Cull, Alyssa, Maura, Francesco, Sanders, Mathijs A., Cagan, Alex T. J., McDonald, Craig, Belmonte, Miriam, Shepherd, Mairi S., Vieira Braga, Felipe A., Osborne, Robert J., Mahbubani, Krishnaa, Martincorena, Iñigo, Laurenti, Elisa, Green, Anthony R., Getz, Gad, Polak, Paz, Saeb-Parsy, Kourosh, Hodson, Daniel J., Kent, David G., Campbell, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402440/
https://www.ncbi.nlm.nih.gov/pubmed/35948631
http://dx.doi.org/10.1038/s41586-022-05072-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402440/
https://www.ncbi.nlm.nih.gov/pubmed/35948631
http://dx.doi.org/10.1038/s41586-022-05072-7

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