Cdk5 regulates IP3R1-mediated Ca(2+) dynamics and Ca(2+)-mediated cell proliferation

Loss of cyclin-dependent kinase 5 (Cdk5) in the mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) increases ER–mitochondria tethering and ER Ca(2+) transfer to the mitochondria, subsequently increasing mitochondrial Ca(2+) concentration ([Ca(2+)](mt)). This suggests a role for Cdk5...

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Detalles Bibliográficos
Autores principales: NavaneethaKrishnan, Saranya, Law, Vincent, Lee, Jungkwon, Rosales, Jesusa L., Lee, Ki-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402492/
https://www.ncbi.nlm.nih.gov/pubmed/36001172
http://dx.doi.org/10.1007/s00018-022-04515-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402492/
https://www.ncbi.nlm.nih.gov/pubmed/36001172
http://dx.doi.org/10.1007/s00018-022-04515-8

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