Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors

The adenomatous polyposis coli (APC)–Rho guanine nucleotide exchange factor 4 (Asef) protein–protein interaction (PPI) is essential for colorectal cancer metastasis, making it a promising drug target. Herein, we obtain a sensitivity-enhanced tracer (tracer 7) with a high binding affinity (K(d) = 0.0...

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Detalles Bibliográficos
Autores principales: Zhong, Jie, Guo, Yuegui, Lu, Shaoyong, Song, Kun, Wang, Ying, Feng, Li, Zheng, Zhen, Zhang, Qiufen, Wei, Jiacheng, Sang, Peng, Shi, Yan, Cai, Jianfeng, Chen, Guoqiang, Liu, Chen-Ying, Yang, Xiuyan, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402538/
https://www.ncbi.nlm.nih.gov/pubmed/36002443
http://dx.doi.org/10.1038/s41467-022-32612-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402538/
https://www.ncbi.nlm.nih.gov/pubmed/36002443
http://dx.doi.org/10.1038/s41467-022-32612-6

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