Effects of a novel toll-like receptor 4 antagonist IAXO-102 in a murine model of chemotherapy-induced gastrointestinal toxicity

INTRODUCTION: Gastrointestinal mucositis (GIM) is a side effect of high-dose irinotecan (CPT-11), causing debilitating symptoms that are often poorly managed. The role of TLR4 in the development of GIM has been clearly demonstrated. We, therefore, aimed to investigate the potential of the TLR4 antag...

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Detalles Bibliográficos
Autores principales: Tam, Janine S. Y., Crame, Elise E., Elz, Aurelia S., Coller, Janet K., Wignall, Anthony, Prestidge, Clive A., Bowen, Joanne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402738/
https://www.ncbi.nlm.nih.gov/pubmed/35962138
http://dx.doi.org/10.1007/s00280-022-04463-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402738/
https://www.ncbi.nlm.nih.gov/pubmed/35962138
http://dx.doi.org/10.1007/s00280-022-04463-x

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