Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase

Isopenicillin N synthase (IPNS) catalyzes formation of the β-lactam and thiazolidine rings of isopenicillin N from its linear tripeptide l-δ-(α-aminoadipoyl)-l-cysteinyl-d-valine (ACV) substrate in an iron- and dioxygen (O(2))-dependent four-electron oxidation without precedent in current synthetic...

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Detalles Bibliográficos
Autores principales: Rabe, Patrick, Walla, Carla C., Goodyear, Noelle K., Welsh, Jordan, Southwart, Rebecca, Clifton, Ian, Linyard, James D.S., Tumber, Anthony, Claridge, Tim D.W., Myers, William K., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403350/
https://www.ncbi.nlm.nih.gov/pubmed/35835215
http://dx.doi.org/10.1016/j.jbc.2022.102249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403350/
https://www.ncbi.nlm.nih.gov/pubmed/35835215
http://dx.doi.org/10.1016/j.jbc.2022.102249

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