Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line

In this study, we present the synthesis, kinetic studies of inhibitory activity toward aldo-keto reductase 1C (AKR1C) enzymes, and anticancer potential toward chemoresistant ovarian cancer of 10 organoruthenium compounds bearing diketonate (1–6) and hydroxyquinolinate (7–10) chelating ligands with t...

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Detalles Bibliográficos
Autores principales: Kljun, Jakob, Pavlič, Renata, Hafner, Eva, Lipec, Tanja, Moreno-Da Silva, Sara, Tič, Primož, Turel, Iztok, Büdefeld, Tomaž, Stojan, Jure, Rižner, Tea Lanišnik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403717/
https://www.ncbi.nlm.nih.gov/pubmed/36034868
http://dx.doi.org/10.3389/fphar.2022.920379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403717/
https://www.ncbi.nlm.nih.gov/pubmed/36034868
http://dx.doi.org/10.3389/fphar.2022.920379

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