Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival

Activating anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) mutations occur in pediatric neuroblastoma and are associated with poor prognosis. To study ALK-activating mutations in a genetically controllable system, we employed CRIPSR/Cas9, incorporating orthologs of the human oncogeni...

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Detalles Bibliográficos
Autores principales: Pfeifer, Kathrin, Wolfstetter, Georg, Anthonydhason, Vimala, Masudi, Tafheem, Arefin, Badrul, Bemark, Mats, Mendoza-Garcia, Patricia, Palmer, Ruth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403751/
https://www.ncbi.nlm.nih.gov/pubmed/35972154
http://dx.doi.org/10.1242/dmm.049591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403751/
https://www.ncbi.nlm.nih.gov/pubmed/35972154
http://dx.doi.org/10.1242/dmm.049591

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