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Advances in covalent drug discovery

Covalent drugs have been used to treat diseases for more than a century, but tools that facilitate the rational design of covalent drugs have emerged more recently. The purposeful addition of reactive functional groups to existing ligands can enable potent and selective inhibition of target proteins...

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Detalles Bibliográficos
Autores principales: Boike, Lydia, Henning, Nathaniel J., Nomura, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403961/
https://www.ncbi.nlm.nih.gov/pubmed/36008483
http://dx.doi.org/10.1038/s41573-022-00542-z