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BF(3)·Et(2)O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides

Annulation reaction of α-keto acids with cyclic or acyclic aliphatic ketones is reported herein to divergently access γ-hydroxy-butenolides and γ-alkylidene-butenolides depending on the amount of BF(3)·Et(2)O. This protocol features good functional tolerance and ease of operation, to open a route to...

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Detalles Bibliográficos
Autores principales: Cheng, Zhenfeng, Gu, Qingyun, Xie, Yushan, Zhang, Yanan, Zeng, Xiaobao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404108/
https://www.ncbi.nlm.nih.gov/pubmed/36128547
http://dx.doi.org/10.1039/d2ra04546j