BF(3)·Et(2)O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides

Annulation reaction of α-keto acids with cyclic or acyclic aliphatic ketones is reported herein to divergently access γ-hydroxy-butenolides and γ-alkylidene-butenolides depending on the amount of BF(3)·Et(2)O. This protocol features good functional tolerance and ease of operation, to open a route to...

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Detalles Bibliográficos
Autores principales: Cheng, Zhenfeng, Gu, Qingyun, Xie, Yushan, Zhang, Yanan, Zeng, Xiaobao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404108/
https://www.ncbi.nlm.nih.gov/pubmed/36128547
http://dx.doi.org/10.1039/d2ra04546j
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author Cheng, Zhenfeng
Gu, Qingyun
Xie, Yushan
Zhang, Yanan
Zeng, Xiaobao
author_facet Cheng, Zhenfeng
Gu, Qingyun
Xie, Yushan
Zhang, Yanan
Zeng, Xiaobao
author_sort Cheng, Zhenfeng
collection PubMed
description Annulation reaction of α-keto acids with cyclic or acyclic aliphatic ketones is reported herein to divergently access γ-hydroxy-butenolides and γ-alkylidene-butenolides depending on the amount of BF(3)·Et(2)O. This protocol features good functional tolerance and ease of operation, to open a route to access butenolides via an annulation and dehydration process.
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spelling pubmed-94041082022-09-19 BF(3)·Et(2)O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides Cheng, Zhenfeng Gu, Qingyun Xie, Yushan Zhang, Yanan Zeng, Xiaobao RSC Adv Chemistry Annulation reaction of α-keto acids with cyclic or acyclic aliphatic ketones is reported herein to divergently access γ-hydroxy-butenolides and γ-alkylidene-butenolides depending on the amount of BF(3)·Et(2)O. This protocol features good functional tolerance and ease of operation, to open a route to access butenolides via an annulation and dehydration process. The Royal Society of Chemistry 2022-08-25 /pmc/articles/PMC9404108/ /pubmed/36128547 http://dx.doi.org/10.1039/d2ra04546j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Cheng, Zhenfeng
Gu, Qingyun
Xie, Yushan
Zhang, Yanan
Zeng, Xiaobao
BF(3)·Et(2)O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides
title BF(3)·Et(2)O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides
title_full BF(3)·Et(2)O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides
title_fullStr BF(3)·Et(2)O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides
title_full_unstemmed BF(3)·Et(2)O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides
title_short BF(3)·Et(2)O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides
title_sort bf(3)·et(2)o-mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404108/
https://www.ncbi.nlm.nih.gov/pubmed/36128547
http://dx.doi.org/10.1039/d2ra04546j
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