Melatonin promotes sirtuin 1 expression and inhibits IRE1α–XBP1S–CHOP to reduce endoplasmic reticulum stress–mediated apoptosis in chondrocytes

Osteoarthritis (OA) is the most common chronic disease characterized by a loss of chondrocytes and the degeneration of cartilage. Inflammation plays an important role in the pathogenesis and progression of OA via the activation of the endoplasmic reticulum (ER) stress signaling pathway. In this stud...

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Detalles Bibliográficos
Autores principales: Qin, Kunpeng, Tang, Hao, Ren, Yi, Yang, Di, Li, Yetian, Huang, Wei, Wu, Yunfeng, Yin, Zongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404507/
https://www.ncbi.nlm.nih.gov/pubmed/36034777
http://dx.doi.org/10.3389/fphar.2022.940629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404507/
https://www.ncbi.nlm.nih.gov/pubmed/36034777
http://dx.doi.org/10.3389/fphar.2022.940629

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