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Soluble (Pro)Renin Receptor Levels Are Regulated by Plasma Renin Activity and Correlated with Edema in Mice and Humans with HFrEF

Symptomatic heart failure with reduced ejection fraction (HFrEF) is characterized by edema and chronic pathological activation of the classical renin–angiotensin–aldosterone system (RAAS). The soluble (pro)renin receptor (s(P)RR) is released into circulation by proteolytic cleavage of tissue express...

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Detalles Bibliográficos
Autores principales: Gladysheva, Inna P., Sullivan, Ryan D., Ramanathan, Kodangudi, Reed, Guy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405551/
https://www.ncbi.nlm.nih.gov/pubmed/36009420
http://dx.doi.org/10.3390/biomedicines10081874