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An Interpretable Machine-Learning Algorithm to Predict Disordered Protein Phase Separation Based on Biophysical Interactions

Protein phase separation is increasingly understood to be an important mechanism of biological organization and biomaterial formation. Intrinsically disordered protein regions (IDRs) are often significant drivers of protein phase separation. A number of protein phase-separation-prediction algorithms...

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Detalles Bibliográficos
Autores principales: Cai, Hao, Vernon, Robert M., Forman-Kay, Julie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405563/
https://www.ncbi.nlm.nih.gov/pubmed/36009025
http://dx.doi.org/10.3390/biom12081131