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Internal Ribosome Entry Site (IRES)-Mediated Translation and Its Potential for Novel mRNA-Based Therapy Development

Many conditions can benefit from RNA-based therapies, namely, those targeting internal ribosome entry sites (IRESs) and their regulatory proteins, the IRES trans-acting factors (ITAFs). IRES-mediated translation is an alternative mechanism of translation initiation, known for maintaining protein syn...

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Detalles Bibliográficos
Autores principales: Marques, Rita, Lacerda, Rafaela, Romão, Luísa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405587/
https://www.ncbi.nlm.nih.gov/pubmed/36009412
http://dx.doi.org/10.3390/biomedicines10081865