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Discovery and Validation of Clinically Relevant Long Non-Coding RNAs in Colorectal Cancer

SIMPLE SUMMARY: Recent efforts in biomedical research have focused on the identification of molecular biomarkers to improve the diagnosis, prognosis and eventually treatment of the most common human diseases worldwide, including cancer. In this context, a large number of studies point to a pivotal r...

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Autores principales: Snyder, Madison, Iraola-Guzmán, Susana, Saus, Ester, Gabaldón, Toni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405614/
https://www.ncbi.nlm.nih.gov/pubmed/36010859
http://dx.doi.org/10.3390/cancers14163866
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author Snyder, Madison
Iraola-Guzmán, Susana
Saus, Ester
Gabaldón, Toni
author_facet Snyder, Madison
Iraola-Guzmán, Susana
Saus, Ester
Gabaldón, Toni
author_sort Snyder, Madison
collection PubMed
description SIMPLE SUMMARY: Recent efforts in biomedical research have focused on the identification of molecular biomarkers to improve the diagnosis, prognosis and eventually treatment of the most common human diseases worldwide, including cancer. In this context, a large number of studies point to a pivotal role of long non-coding RNAs (lncRNAs) in the pathophysiology of carcinogenesis, suggesting diagnostic or therapeutic potential. However, for most of them, supporting evidence is scarce and often based on a single large-scale analysis. Here, focusing on colorectal cancer (CRC), we present an overview of the main approaches for discovering and validating lncRNA candidate molecules, and provide a curated list of the most promising lncRNAs associated with this malignancy. ABSTRACT: Colorectal cancer (CRC) is the third most prevalent cancer worldwide, with nearly two million newly diagnosed cases each year. The survival of patients with CRC greatly depends on the cancer stage at the time of diagnosis, with worse prognosis for more advanced cases. Consequently, considerable effort has been directed towards improving population screening programs for early diagnosis and identifying prognostic markers that can better inform treatment strategies. In recent years, long non-coding RNAs (lncRNAs) have been recognized as promising molecules, with diagnostic and prognostic potential in many cancers, including CRC. Although large-scale genome and transcriptome sequencing surveys have identified many lncRNAs that are altered in CRC, most of their roles in disease onset and progression remain poorly understood. Here, we critically review the variety of detection methods and types of supporting evidence for the involvement of lncRNAs in CRC. In addition, we provide a reference catalog that features the most clinically relevant lncRNAs in CRC. These lncRNAs were selected based on recent studies sorted by stringent criteria for both supporting experimental evidence and reproducibility.
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spelling pubmed-94056142022-08-26 Discovery and Validation of Clinically Relevant Long Non-Coding RNAs in Colorectal Cancer Snyder, Madison Iraola-Guzmán, Susana Saus, Ester Gabaldón, Toni Cancers (Basel) Review SIMPLE SUMMARY: Recent efforts in biomedical research have focused on the identification of molecular biomarkers to improve the diagnosis, prognosis and eventually treatment of the most common human diseases worldwide, including cancer. In this context, a large number of studies point to a pivotal role of long non-coding RNAs (lncRNAs) in the pathophysiology of carcinogenesis, suggesting diagnostic or therapeutic potential. However, for most of them, supporting evidence is scarce and often based on a single large-scale analysis. Here, focusing on colorectal cancer (CRC), we present an overview of the main approaches for discovering and validating lncRNA candidate molecules, and provide a curated list of the most promising lncRNAs associated with this malignancy. ABSTRACT: Colorectal cancer (CRC) is the third most prevalent cancer worldwide, with nearly two million newly diagnosed cases each year. The survival of patients with CRC greatly depends on the cancer stage at the time of diagnosis, with worse prognosis for more advanced cases. Consequently, considerable effort has been directed towards improving population screening programs for early diagnosis and identifying prognostic markers that can better inform treatment strategies. In recent years, long non-coding RNAs (lncRNAs) have been recognized as promising molecules, with diagnostic and prognostic potential in many cancers, including CRC. Although large-scale genome and transcriptome sequencing surveys have identified many lncRNAs that are altered in CRC, most of their roles in disease onset and progression remain poorly understood. Here, we critically review the variety of detection methods and types of supporting evidence for the involvement of lncRNAs in CRC. In addition, we provide a reference catalog that features the most clinically relevant lncRNAs in CRC. These lncRNAs were selected based on recent studies sorted by stringent criteria for both supporting experimental evidence and reproducibility. MDPI 2022-08-10 /pmc/articles/PMC9405614/ /pubmed/36010859 http://dx.doi.org/10.3390/cancers14163866 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Snyder, Madison
Iraola-Guzmán, Susana
Saus, Ester
Gabaldón, Toni
Discovery and Validation of Clinically Relevant Long Non-Coding RNAs in Colorectal Cancer
title Discovery and Validation of Clinically Relevant Long Non-Coding RNAs in Colorectal Cancer
title_full Discovery and Validation of Clinically Relevant Long Non-Coding RNAs in Colorectal Cancer
title_fullStr Discovery and Validation of Clinically Relevant Long Non-Coding RNAs in Colorectal Cancer
title_full_unstemmed Discovery and Validation of Clinically Relevant Long Non-Coding RNAs in Colorectal Cancer
title_short Discovery and Validation of Clinically Relevant Long Non-Coding RNAs in Colorectal Cancer
title_sort discovery and validation of clinically relevant long non-coding rnas in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405614/
https://www.ncbi.nlm.nih.gov/pubmed/36010859
http://dx.doi.org/10.3390/cancers14163866
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