Cargando…
Novel Scaffolds for Modulation of NOD2 Identified by Pharmacophore-Based Virtual Screening
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an innate immune pattern recognition receptor responsible for the recognition of bacterial peptidoglycan fragments. Given its central role in the formation of innate and adaptive immune responses, NOD2 represents a valuable tar...
Autores principales: | Guzelj, Samo, Tomašič, Tihomir, Jakopin, Žiga |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405794/ https://www.ncbi.nlm.nih.gov/pubmed/36008948 http://dx.doi.org/10.3390/biom12081054 |
Ejemplares similares
-
Discovery
of Desmuramylpeptide NOD2 Agonists with
Single-Digit Nanomolar Potency
por: Guzelj, Samo, et al.
Publicado: (2022) -
Covalently
Conjugated NOD2/TLR7 Agonists Are Potent
and Versatile Immune Potentiators
por: Guzelj, Samo, et al.
Publicado: (2022) -
Lipidation of NOD2 Agonists with Adamantane and Stearoyl Moieties Differentially Regulates Their In Vivo Adjuvant Activity
por: Guzelj, Samo, et al.
Publicado: (2022) -
Synthesis of Conformationally Constrained d-Glu-meso-DAP Analogs as Innate Immune Agonists
por: Guzelj, Samo, et al.
Publicado: (2020) -
Nucleotide-Binding Oligomerization Domain 1/Toll-Like Receptor 4 Co-Engagement Promotes Non-Specific Immune Response Against K562 Cancer Cells
por: Guzelj, Samo, et al.
Publicado: (2022)