Disrupting Effects of Osteogenesis Imperfecta Mutations Could Be Predicted by Local Hydrogen Bonding Energy

Osteogenesis imperfecta(OI) is a disease caused by substitution in glycine residues with different amino acids in type I collagen (Gly-Xaa-Yaa)n. Collagen model peptides can capture the thermal stability loss of the helix after Gly mutations, most of which are homotrimers. However, a majority of nat...

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Detalles Bibliográficos
Autores principales: Qiang, Shumin, Lu, Cheng, Xu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405839/
https://www.ncbi.nlm.nih.gov/pubmed/36008998
http://dx.doi.org/10.3390/biom12081104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405839/
https://www.ncbi.nlm.nih.gov/pubmed/36008998
http://dx.doi.org/10.3390/biom12081104

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