Cargando…

Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D(2)/D(3) Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases

Most neurodegenerative diseases are multifactorial, and the discovery of several molecular mechanisms related to their pathogenesis is constantly advancing. Dopamine and dopaminergic receptor subtypes are involved in the pathophysiology of several neurological disorders, such as schizophrenia, depre...

Descripción completa

Detalles Bibliográficos
Autores principales:	da Silva Cunha, Thayssa Tavares, Silva, Rafaela Ribeiro, Rodrigues, Daniel Alencar, de Sena Murteira Pinheiro, Pedro, Kronenberger, Thales, Sant’Anna, Carlos Maurício R., Noël, François, Fraga, Carlos Alberto Manssour
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405847/ https://www.ncbi.nlm.nih.gov/pubmed/36009006 http://dx.doi.org/10.3390/biom12081112

Ejemplares similares

The Magic Methyl and Its Tricks in Drug Discovery and Development
por: Pinheiro, Pedro de Sena Murteira, et al.
Publicado: (2023)

Methyl Effect on the Metabolism, Chemical Stability, and Permeability Profile of Bioactive N-Sulfonylhydrazones
por: Guedes, Jéssica de Siqueira, et al.
Publicado: (2022)

Editorial: Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases?
por: Viegas, Claudio, et al.
Publicado: (2020)

Correction: Design, synthesis, and evaluation of bitopic arylpiperazine-phthalimides as selective dopamine D(3) receptor agonists
por: Cao, Yongkai, et al.
Publicado: (2018)

Novel Single Inhibitor of HDAC6/8 and Dual Inhibitor of PI3K/HDAC6 as Potential Alternative Treatments for Prostate Cancer
por: Guerra, Fabiana Sélos, et al.
Publicado: (2021)

Solid-Phase Synthesis of Arylpiperazine Derivatives and Implementation of the Distributed Drug Discovery (D3) Project in the Search for CNS Agents
por: Zajdel, Paweł, et al.
Publicado: (2011)

Characterization of Amide Bond Conformers for a Novel Heterocyclic Template of N-acylhydrazone Derivatives
por: Lopes, Alexandra Basilio, et al.
Publicado: (2013)

Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties
por: Mastromarino, Margherita, et al.
Publicado: (2022)

Photocatalysis and Kinetic Resolution by Lithiation to Give Enantioenriched 2-Arylpiperazines
por: Das, Anjan, et al.
Publicado: (2023)

Inhibitor induced conformational changes in SARS-COV-2 papain-like protease
por: Ferreira, Glaucio Monteiro, et al.
Publicado: (2022)

Synthesis and Antitumor Activity of Novel Arylpiperazine Derivatives Containing the Saccharin Moiety
por: Chen, Hong, et al.
Publicado: (2017)

Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers
por: Chu, Yeonjeong, et al.
Publicado: (2020)

Imidazole: Synthesis, Functionalization and Physicochemical Properties of a Privileged Structure in Medicinal Chemistry
por: Tolomeu, Heber Victor, et al.
Publicado: (2023)

Design, Synthesis and Biological Activity Evaluation of Arylpiperazine Derivatives for the Treatment of Neuropathic Pain
por: Chen, Yin, et al.
Publicado: (2011)

Synthesis, bioactivity, and molecular docking of novel arylpiperazine derivatives as potential AR antagonists
por: Qi, Yueheng, et al.
Publicado: (2022)

Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents
por: Çalışkan, Burcu, et al.
Publicado: (2018)

Antiprotozoal Activity of (E)-Cinnamic N-Acylhydrazone Derivatives
por: Carvalho, Samir Aquino, et al.
Publicado: (2014)

Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist
por: Rashidian, Azam, et al.
Publicado: (2022)

Mechanism Exploration of Arylpiperazine Derivatives Targeting the 5-HT(2A) Receptor by In Silico Methods
por: Lin, Feng, et al.
Publicado: (2017)

The Structure–Antimicrobial Activity Relationships of a Promising Class of the Compounds Containing the N-Arylpiperazine Scaffold †
por: Malík, Ivan, et al.
Publicado: (2016)

Synthesis and Cytotoxic Activity Evaluation of Novel Arylpiperazine Derivatives on Human Prostate Cancer Cell Lines
por: Chen, Hong, et al.
Publicado: (2014)

Design, Synthesis, and Structure–Activity Relationship Studies of a Series of [4-(4-Carboxamidobutyl)]-1-arylpiperazines: Insights into Structural Features Contributing to Dopamine D3 versus D2 Receptor Subtype Selectivity
por: Ananthan, Subramaniam, et al.
Publicado: (2014)

Comparative Incidence of Conformational, Neurodegenerative Disorders
por: de Pedro-Cuesta, Jesús, et al.
Publicado: (2015)

Vitamin D and neurodegenerative diseases
por: Wang, Weixia, et al.
Publicado: (2023)

Design, Synthesis and Biological Evaluation of Novel N-Arylpiperazines Containing a 4,5-Dihydrothiazole Ring
por: Andreozzi, Giorgia, et al.
Publicado: (2023)

Novel Arylpiperazine Derivatives of Salicylamide with α(1)-Adrenolytic Properties Showed Antiarrhythmic and Hypotensive Properties in Rats
por: Żmudzka, Elżbieta, et al.
Publicado: (2022)

Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D(2) Receptor
por: Silva, Rafaela R., et al.
Publicado: (2019)

Role of Prostaglandins in Neuroinflammatory and Neurodegenerative Diseases
por: Lima, Isabel Vieira de Assis, et al.
Publicado: (2012)

Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics
por: Sant’Anna, Thaís B., et al.
Publicado: (2023)

The Chlorate-Iodine-Nitrous Acid Clock Reaction
por: Sant'Anna, Rafaela T. P., et al.
Publicado: (2014)

Synthesis and (In Vitro) Antimycobacterial Activity of Novel N-Arylpiperazines Containing an Ethane-1,2-diyl Connecting Chain
por: Goněc, Tomáš, et al.
Publicado: (2017)

Synthesis and Determination of Physicochemical Properties of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Alkoxyethoxybenzoates
por: Marvanova, Pavlina, et al.
Publicado: (2016)

Synthesis and Characterization of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Propoxybenzoates and Their Hydrochloride Salts
por: Marvanova, Pavlina, et al.
Publicado: (2016)

Multi-Spectroscopic and Theoretical Analysis on the Interaction between Human Serum Albumin and a Capsaicin Derivative—RPF101
por: Chaves, Otávio Augusto, et al.
Publicado: (2018)

Correction: Comparative Incidence of Conformational, Neurodegenerative Disorders
por: de Pedro-Cuesta, Jesús, et al.
Publicado: (2015)

Mammalian prion protein (PrP) forms conformationally different amyloid intracellular aggregates in bacteria
por: Macedo, Bruno, et al.
Publicado: (2015)

X-ray Crystallography, DFT Calculations and Molecular Docking of Indole-Arylpiperazine Derivatives as α(1A)-Adrenoceptor Antagonists
por: Xu, Wei, et al.
Publicado: (2015)

Solvates of New Arylpiperazine Salicylamide Derivative-a Multi-Technique Approach to the Description of 5 HTR Ligand Structure and Interactions
por: Pindelska, Edyta, et al.
Publicado: (2021)

HilE represses the activity of the Salmonella virulence regulator HilD via a mechanism distinct from that of intestinal long-chain fatty acids
por: Joiner, Joe D., et al.
Publicado: (2023)

Neurodegenerative Diseases: Multifactorial Conformational Diseases and Their Therapeutic Interventions
por: Sheikh, Saba, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vl6cs91hcllt34ktk1cm83t1na